For all I do like muzzle stuffers I have to admit I'm in camp cartridge. More so a design like a flintlock. Yes they're still I viable hunting option, in the same way a traditional sling, bolas, spear or wooden club is. But I can't help but think they've been largely replaced by modern systems for a good reason. Even taking lock times and accuracy out of the equation, convenience would be my major draw factor. As for making powder, yeah, anyone can make a basic black powder, it'll burn, it might even go bang, but it probably won't be all that consistent. Assuming of course you aren't making it in a laboratory. Its also a little more unstable, I remember a very very learned chap from the amateur pyro community having a mishap with black powder in ball mills.
As I said I do enjoy muzzle loaders, they're a lot of fun. I just think there are better and safer options. And as a member of the British muzzle loading association once said to me (after a few aim straighteners in the bisley pavilion) "muzzle loaders using black powder all take 21 minutes and half a second to take every shot. Half a second for the shot to go off, a minute to reload, 10 minutes for the smoke to clear and 10 minutes to put the fires out!"