Inhalation:
Causes irritation to the respiratory tract. Symptoms may include coughing, shortness of breath. High concentrations can cause pulmonary edema.
Ingestion:
Ingestion of solid or high concentrations causes severe distress of gastro-intestinal system with possible burns and edema; slow pulse; shock with fall of blood pressure. May be fatal. Ingestion of concentrations up to 1% causes burning of the throat, nausea, vomiting, and abdominal pain; 2-3% causes anemia and swelling of the throat with possible suffocation; 4-5% may cause kidney damage.
Skin Contact:
Dry crystals and concentrated solutions are caustic causing redness, pain, severe burns, brown stains in the contact area and possible hardening of outer skin layer. Diluted solutions are only mildly irritating to the skin.
Eye Contact:
Eye contact with crystals (dusts) and concentrated solutions causes severe irritation, redness, blurred vision and can cause severe damage, possibly permanent.
Chronic Exposure:
Prolonged skin contact may cause irritation, defatting, and dermatitis. Chronic manganese poisoning can result from excessive inhalation exposure to manganese dust and involves impairment of the central nervous system. Early symptoms include sluggishness, sleepiness, and weakness in the legs. Advanced cases have shown symptoms of fixed facial expression, emotional disturbances, spastic gait, and falling.