I am presently moving from synthetic bags to down bags, so haven't made any real definite decision yet.
I do find down bags breath better, but also require more protection.
Summer I am happy to wear cotton, top and trousers; or the mix fibre outdoor clothing in my bag.
In winder its a dry set on for sleep, wet ones go on top or underneath sleeping system. Slightly damp then they can stay on (if they haven't dried fairly well by end of supper then its a change). Properly wet then they have to come off as you can't get good sleep when wet. I used to change back into the wet kit each morning. Keeping one set of clothes very dry is a must.
If its very cold then I am a huge fan of fibre pile as a top and zip on trousers. Next to the skin is best but can be a mid layer over cotton. Softies are great, but a fibre pile better for this kind of thing. (Annoyingly Fibre Pile is heavy, too heavy to carry a spare and so has to be a main garment). The fibre pile trousers came off once the sun was up, or once staring work; helps stop the shivers before breakfast.
I agree cotton is a terrible choice, but I've got away with it for a while now. Wool is better and I'm old enough to remember the Army "Hairy Mary" shirts of old; they were excellent once broken in. Suppose marino wool is the modern take on it.
I do have and have used a Parachute silk top and bottoms which are featherweight and do seem to work; must pack them again sometime. Great for hut use.
So its shirt and trousers that are dry, light weight or fibre pile.
I grew up with little central heating and sleeping out was never a problem. Feeling the cold became an issue when I got married; central heating and a hot wife! Now I need one season up on all my thermals.
Hot water bottles: have pros and cons. They should always have a cover so not to burn you. They can make you over heat early in the night so produce sweat; you can wake up cold in the morning. They can leak. They are not an excuse to have a lower rated sleeping system for the conditions. They can help dry a damp sleeping bag (night two/three), or as an aid to drying them out. They can help a hyperthermic casualty. I prefer a thermos full of hot water, just in case a hot brew is required during the night.
Lastly, the bigger the tent the more admin that is possible. However, don't start the nights sleep wet as it really will sap you fast. 3am mid way through the night is the wrong time to start sorting yourself out from being lazy having not bothered earlier.